The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K

Slabicki M, Kozicka Z, Petzold G, Li YD, Manojkumar M, Bunker RD, Donovan KA, Sievers QL, Koeppel J, Suchyta D, et al. The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K. Nature. 2020;585:293-297.
NOTES

Slabicki, MikolajKozicka, ZuzannaPetzold, GeorgLi, Yen-DerManojkumar, ManishaBunker, Richard DDonovan, Katherine ASievers, Quinlan LKoeppel, JonasSuchyta, DakotaSperling, Adam SFink, Emma CGasser, Jessica AWang, Li RCorsello, Steven MSellar, Rob SJan, MaxGillingham, DennisScholl, ClaudiaFrohling, StefanGolub, Todd RFischer, Eric SThoma, Nicolas HEbert, Benjamin LengP50 CA206963/CA/NCI NIH HHS/R01 HL082945/HL/NHLBI NIH HHS/T32 GM007753/GM/NIGMS NIH HHS/HHMI/Howard Hughes Medical Institute/R01 CA214608/CA/NCI NIH HHS/R01 CA218278/CA/NCI NIH HHS/P01 CA066996/CA/NCI NIH HHS/K08 CA230220/CA/NCI NIH HHS/Research Support, N.I.H., ExtramuralResearch Support, Non-U.S. Gov'tEnglandNature. 2020 Sep;585(7824):293-297. doi: 10.1038/s41586-020-2374-x. Epub 2020 Jun 3.

Last updated on 05/10/2021