Majumder PK, Yeh JJ, George DJ, Febbo PG, Kum J, Xue Q, Bikoff R, Ma H, Kantoff PW, Golub TR, et al. Prostate intraepithelial neoplasia induced by prostate restricted Akt activation: the MPAKT model. Proc Natl Acad Sci U S A. 2003;100:7841–6.
NOTES
Majumder, Pradip KYeh, Jen JenGeorge, Daniel JFebbo, Phillip GKum, JenniferXue, QiBikoff, RachelMa, HongfengKantoff, Philip WGolub, Todd RLoda, MassimoSellers, William RengP01 CA089021/CA/NCI NIH HHS/P01 CA89021/CA/NCI NIH HHS/Research Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7841-6. doi: 10.1073/pnas.1232229100. Epub 2003 Jun 10.
Abstract
To determine whether Akt activation was sufficient for the transformation of normal prostate epithelial cells, murine prostate restricted Akt kinase activity was generated in transgenic mice (MPAKT mice). Akt expression led to p70S6K activation, prostatic intraepithelial neoplasia (PIN), and bladder obstruction. mRNA expression profiles from MPAKT ventral prostate revealed similarities to human cancer and an angiogenic signature that included three angiogenin family members, one of which was found elevated in the plasma of men with prostate cancer. Thus, the MPAKT model may be useful in studying the role of Akt in prostate epithelial cell transformation and in the discovery of molecular markers relevant to human disease.
Last updated on 02/17/2021