Getz G, Hofling H, Mesirov JP, Golub TR, Meyerson M, Tibshirani R, Lander ES. Comment on "The consensus coding sequences of human breast and colorectal cancers". Science. 2007;317:1500.
NOTES
Getz, GadHofling, HolgerMesirov, Jill PGolub, Todd RMeyerson, MatthewTibshirani, RobertLander, Eric SengCommentResearch Support, N.I.H., ExtramuralResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, Non-P.H.S.Science. 2007 Sep 14;317(5844):1500. doi: 10.1126/science.1138764.
Abstract
Sjoblom et al. (Research Article, 13 October 2006, p. 268) reported nearly 200 novel cancer genes said to have a 90% probability of being involved in colon or breast cancer. However, their analysis raises two statistical concerns. When these concerns are addressed, few genes with significantly elevated mutation rates remain. Although the biological methodology in Sjoblom et al. is sound, more samples are needed to achieve sufficient power.
Last updated on 02/17/2021